Lung Cancer in a Steel FoundryA Search for Causation
作者:
E. Gibson,
D. McCalla,
C. Kaiser-Farrell,
A. Kerr,
J. Lockington,
C. Hertzman,
J. Rosenfeld,
期刊:
Journal of Occupational Medicine
(OVID Available online 1983)
卷期:
Volume 25,
issue 8
页码: 573-578
ISSN:0096-1736
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
Epidemiological studies suggest an association between excess lung cancer risk and work in ferrous foundries. No causative factors have been identified. The foundry environment is complex, and little is known about the health effects of the levels of known or suspected carcinogens present. As a part of an effort to identify causative factors and to assess current risk, an Ames assay of particulate mutagenicity was undertaken. Mutagenic levels were found to exceed those of urban air and distribution findings were consistent with those of a previous epidemiological study that identified high- and low-risk areas within the foundry. The biological significance of these mutagenic levels is unknown but is under study. A mechanism is suggested to explain current and historical findings.
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