Staging patterns and early cancer detection
作者:
Charles R. Smart,
Kenneth C. Chu,
期刊:
Seminars in Surgical Oncology
(WILEY Available online 1992)
卷期:
Volume 8,
issue 2
页码: 62-72
ISSN:8756-0437
年代: 1992
DOI:10.1002/ssu.2980080204
出版商: John Wiley&Sons, Inc.
关键词: stage shifts;screening;extent of disease
数据来源: WILEY
摘要:
AbstractThere is a great deal of indirect, nonexperimental evidence that a pattern of earlier‐stage disease at diagnosis has a better outcome. Increased early detection activities can change, these stage patterns while various biases and the question of generalizability need to be kept in mind in their interpretation. The indirect evidences of possible benefit from early detection activities includes an increase in the number of cases detected, a pattern of more early‐ and less advanced‐stage cases, an increase in the overall site‐specific survival rate, and a decrease in the case fatality rate. Unless these intermediate markers are favorable, it is unlikely that early detection will reduce mortality. In addition, one should also differentiate a reduced incidence or a change in treatment as a cause for reduced mortality. © 1992 Wiley
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