Antihepatotoxic actions of traditional chinese medicines. 2.The pharmacological interaction of components of Dai‐saiko‐tǒ employing complement‐mediated cytotoxicity in primary cultured mouse hepatocytes
作者:
Yoshinobu Kiso,
Michiko Suzuki,
Masahiro Yasuda,
Hisako Watanabe,
Toshihiko Minegishi,
Hiroshi Hikino,
Ling‐Ling Yang,
Kun‐Ying Yen,
期刊:
Phytotherapy Research
(WILEY Available online 1990)
卷期:
Volume 4,
issue 1
页码: 36-38
ISSN:0951-418X
年代: 1990
DOI:10.1002/ptr.2650040109
出版商: John Wiley&Sons, Ltd.
关键词: traditional Chinese medicines;Dai‐saiko‐tǒ;herbal prescription;antihepatotoxic action;complement‐mediated cytotoxicity;active components;pharmacological interactions
数据来源: WILEY
摘要:
AbstractAntihepatotoxic activities of the components of a traditional Chinese prescription, Dai‐saiko‐tǒ, were examined employing complement‐mediated cytotoxicity in primary cultured mouse hepatocytes.Bupleuri RadixandScutellariae Radixwere shown to be active in this system but did not reach the levels of activity of the prescription. In combination,Bupleuri Radix‐Scutellariae Radix, Bupleuri Radix‐Zingiberis Rhizoma, Scutellariae Radix‐Pinelliae Tuber and Bupleuri Radix‐Zingiberis Rhizoma, exhibited effects comparable to the original prescription. It was therefore concluded that the antihepatotoxic activity of Dai‐saiko‐tǒ is due to the pharmacological interactions of their constituents. In addition, a difference in antihepatotoxic activity ofBupleuri RadixandAurantii Fructus Immaturuswas observed between their water extracts and 50% aqueous ethanol extracts, indicating that active principles in each extract of the prescription seemed to be different and, therefore, the method of extraction was an important factor in the clinical
点击下载:
PDF
(228KB)
返 回