T-Lymphocytes and Serum Inhibitors of Cell-Mediated Immunity in Renal Insufficiency
作者:
J.L. Touraine,
F. Touraine,
J.P. Revillard,
J. Brochier,
J. Traeger,
期刊:
Nephron
(Karger Available online 1975)
卷期:
Volume 14,
issue 2
页码: 195-208
ISSN:1660-8151
年代: 1975
DOI:10.1159/000180448
出版商: S. Karger AG
关键词: Acute renal failure;Chronic renal failure;Delayed hypersensitivity;Lymphocyte cultures;Serum inhibitors;Methylguanidine;T-lymphocytes;Cell-mediated immunodeficiency
数据来源: Karger
摘要:
In acute as well as chronic renal insufficiency significant immunological abnormalities were found: diminution of delayed hypersensitivity skin reactions, lymphopenia, reduction of the absolute but not relative number of peripheral blood T-lymphocytes. Responses of lymphocytes from uremic patients to PHA, allogeneic cells, or antigens were normal when lymphocyte cultures were performed in allologous serum from a healthy individual. Sera from uremic patients had an inhibitory or toxic effect on stimulation of normal lymphocytes. Such an in vitro inhibitory activity was found not only in the whole serum but alsowhen certain substances retained in renal failure (methylguanidine, larger molecules, etc.)were added in the lymphocyte cultures.
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