Insulin Stimulates Androgen Accumulation in Incubations of Minced Porcine Theca
作者:
Robert L. Barbieri,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1994)
卷期:
Volume 37,
issue 4
页码: 265-269
ISSN:0378-7346
年代: 1994
DOI:10.1159/000292575
出版商: S. Karger AG
关键词: Insulin;Ovary;Androgens
数据来源: Karger
摘要:
Clinical observations indicate that there is an association between hyperinsulinemia and hyperandrogenism in women of reproductive age. The effects of insulin on ovarian steroidogenesis were studied in 4-day incubations of minced porcine theca. Insulin alone significantly stimulated dihydrotestosterone (DHT), testosterone (T) and androstenedione (Δ4A) accumulation in the media as compared to vehicle-treated controls. Insulin alone did not stimulate progesterone (P) accumulation. Insulin plus luteinizing hormone (LH) resulted in significantly greater accumulation of DHT, T and Δ4A than LH alone. Insulin plus LH did not stimulate P accumulation as compared to LH alone. Insulin, at high concentrations, may be a regulator of thecal androgen synthesis.
点击下载:
PDF
(1743KB)
返 回