Reticuloendothelial System Phagocytic Function in Obstructive Jaundice and its Modification by a Muramyl Dipeptide Analogue
作者:
J.A. Pain,
D.St.J. Collier,
A. Ritson,
期刊:
European Surgical Research
(Karger Available online 1987)
卷期:
Volume 19,
issue 1
页码: 16-22
ISSN:0014-312X
年代: 1987
DOI:10.1159/000128676
出版商: S. Karger AG
关键词: Extrahepatic biliary tract obstruction;Reticuloendothelial system;Kupffer cell;Phagocytosis;Muramyl dipeptide;Endotoxin
数据来源: Karger
摘要:
Measurement of reticulo-endothelial system (RES) phagocytic function by clearance of intravenous micro-aggregated human albumin (HMAA) showed prolonged clearance in both patients (p < 0.001) and rats (p < 0.001) with extrahepatic biliary tract obstruction compared with non-jaundiced controls. After the administration of the immune stimulator, N-acetyl-L-α-aminobutyryl-D-isoglutamine, the mean HMAA clearance rate in jaundiced animals was similar to that of non-jaundiced controls. The implications of modifying RES phagocytic function to prevent overspill of endotoxins from the portal to systemic circulation in obstructive jaundice are discussed
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