Effect of Distal Gastrectomy on Gut Hormone Release following Vagal Stimulation in Dogs
作者:
J. Kameyama,
A. Suzuki,
Y. Yasaku,
H. Kuzu,
M. Tsukamoto,
期刊:
European Surgical Research
(Karger Available online 1993)
卷期:
Volume 25,
issue 6
页码: 390-395
ISSN:0014-312X
年代: 1993
DOI:10.1159/000129306
出版商: S. Karger AG
关键词: Distal gastrectomy;Vagal stimulation;Gastrin;Somatostatin;Pancreatic polypeptide
数据来源: Karger
摘要:
The effect of distal gastrectomy on gut hormone release was investigated by electrical stimulation of the posterior truncal vagus in dogs. Peripheral and portal plasma gastrin release was significantly inhibited, but peripheral and portal somatostatin release was unchanged. Peripheral and portal pancreatic polypeptide (PP) release was significantly inhibited. Our results suggest that the following factors might be some of the reasons why the secretion of PP was inhibited after distal gastrectomy: (l)transection of the posterior vagal branches close to the antrum and pylorus which might go to the pancreas; (2) changes in other hormones such as gastrin; (3) elimination of the PP secretagogue from the gastric antrum.
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