Natural Protoberberine Alkaloids from Enantía Chlorantha, Palmatine, Columbamine and Jatrorrhizine for Thioacetamidc-Traumatized Rat Liver
作者:
Pauli Virtanen,
Veijo Lassila,
Thomas Njimi,
Denis Ekotto Mengata,
期刊:
Cells Tissues Organs
(Karger Available online 1988)
卷期:
Volume 131,
issue 2
页码: 166-170
ISSN:1422-6405
年代: 1988
DOI:10.1159/000146507
出版商: S. Karger AG
关键词: Protoberberines;Enantia chlorantha;Rat blood;Liver injury;Liver regeneration
数据来源: Karger
摘要:
Experimental liver injury was provoked experimentally in rats with intraperitoneal injections of thioacetamide. Traumatized rats received further intraperitoneal injections of Hepasor, a protoberberine alkaloid extract from Enαntiα chlorantha (Annonaceae) containing palmatine, columbamine and jatrorrhizine.The development of body weight was kept under continuous control. Biochemical assays of blood plasma, serum alanine transferase (S-ALT), serum alkaline phosphatase (S-AP), serum creatinine S-CREAT, serum hydroxyproline (S-OH-PROL) and serum calcium (S-Ca) were done and liver samples for histological processing were taken.The biochemical results obtained indicate Hepasor exerted a marked influence on the S-ALT activities and S-OH-PROL values in female rats, but more incidental one in male rats. Some reduction in S-AP activity and S-CRE AT values, which was also dependent on sex, was also found. The histological findings in the liver sections of female rats show that Hepasor improves the blood flow and mitotic activity in thioacetamide-traumatized liver
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