Role of extracellular retention of low density lipoproteins in atherosclerosis
作者:
Jan Borén,
Maria Gustafsson,
Kristina Skålén,
Christofer Flood,
Thomas Innerarity,
期刊:
Current Opinion in Lipidology
(OVID Available online 2000)
卷期:
Volume 11,
issue 5
页码: 451-456
ISSN:0957-9672
年代: 2000
出版商: OVID
数据来源: OVID
摘要:
The pathogenesis for atherosclerosis is still unclear, and several hypotheses have been articulated to explain the initiating events in atherogenesis. Although these hypotheses are by no means mutually exclusive, there is a growing body of recent evidence that has led to the concept that subendothelial retention of apolipoprotein B100-containing lipoproteins is the initiating event in atherogenesis. Subsequently, a series of biological responses to this retained material leads to specific molecular and cellular processes that promote lesion formation. The present review assesses some of the studies that support this concept.
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