AbstractIsolated rat liver was perfused with a once‐through technique. Glycogen synthesis was not affected by the presence of lithium (1 or 5 mM) in the perfusion medium. The rate of glycogen breakdown both without and with glucagon stimulation was not affected by lithium (1 mM). The uptake of free fatty acids was stimulated by lithium (5 mM) in the perfusion medium and a trend towards an increase in deposition of triglyceride in the same order of magnitude was see