Brief Communication: Vitamin B1, B2, and B6Augmentation of Tricyclic Antidepressant Treatment in Geriatrie Depression with Cognitive Dysfunction
作者:
BellIris R.,
EdmanJoel S.,
MorrowFrank D.,
MarbyDavid W.,
PerroneGayle,
KayneHerbert L.,
GreenwaldMichcle,
ColeJonathan O.,
期刊:
Journal of the American College of Nutrition
(Taylor Available online 1992)
卷期:
Volume 11,
issue 2
页码: 159-163
ISSN:0731-5724
年代: 1992
DOI:10.1080/07315724.1992.12098238
出版商: Taylor&Francis
关键词: vitamins B1;B2;B6;depression;memory;geriatric;nortriptyline;tricyclic antideprcssants
数据来源: Taylor
摘要:
This was a 4-week randomized, placebo-controlled double-blind study to assess augmentation of open tricyclic antidepressant treatment with 10 mg each of vitamins B1, B2, and B6 in 14 geriatric inpatients with depression. The active vitamin group demonstrated significantly better B2 and B6 status on enzyme activity coefficients and trends toward greater improvement in scores on ratings of depression and cognitive function, as well as in serum nortriptyline levels compared with placebo-treated subjects (Ss). Without specific supplementation, B12 levels increased in Ss receiving B1/B2/B6 and decreased in placebo Ss. These findings offer preliminary support for further investigation of B complex vitamin augmentation in the treatment of geriatric depression.
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