Increase in Serotonin 1A Receptors in the Dentate Gyrus as Revealed by Autoradiographic Analysis Following Repeated Electroconvulsive Shock But Not Imipramine Treatment
作者:
Hiroshi Hayakawa,
Masami Shimizu,
Akira Nishida,
Nobutaka Motohashi,
Shigeto Yamawaki,
期刊:
Neuropsychobiology
(Karger Available online 1994)
卷期:
Volume 30,
issue 2-3
页码: 53-56
ISSN:0302-282X
年代: 1994
DOI:10.1159/000119413
出版商: S. Karger AG
关键词: Electroconvulsive shock;Imipramine;[3H]8-OH-DPAT binding site;5-HT1Areceptor;Quantitative autoradiography;Hippocampus;Dentate gyrus
数据来源: Karger
摘要:
The effects of repeated treatment with electroconvulsive shock (ECS) and imipramine on [3H]8-OH-DPAT binding to serotonin1A (5-HT1A) receptors in the rat brain were studied by quantitative autoradiographic analysis. A large number of binding sites for [3H]8-OH-DPAT were observed in the hippocampus, especially the dentate gyrus, CA1+CA2 field, dorsal raphe nucleus and septum. Repeated treatment with ECS, but not repeated imipramine treatment, significantly increased [3H]8-OH-DPAT binding sites in the dentate gyrus. These results suggest that the increase in [3H]8-OH-DPAT binding sites in the dentate gyrus may be important in ECS therapy for depressive illness.
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