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La pathogénie d’action et l’effet thérapeutique de la cortisone sur les oesophagites corrosives aiguës

 

作者: J.-P. Taillens,  

 

期刊: ORL  (Karger Available online 1969)
卷期: Volume 31, issue 6  

页码: 333-353

 

ISSN:0301-1569

 

年代: 1969

 

DOI:10.1159/000274912

 

出版商: S. Karger AG

 

关键词: Oesophagus;Corrosive lesions;Pathogenic action of corticoids;Indications of corticoid therapy

 

数据来源: Karger

 

摘要:

The author first reviews the action of corticoids in general, then their beneficial as well as unwanted effects on a corrosive lesions of the oesophagus. Management depends above all on the pathology of the lesions, in practice on endoscopic findings. Local contra-indications are severe necrosis and profuse gastric bleeding. Distal (i.e. gastric) injury is more frequent than is commonly realised as ingestion of corrosives precludes its investigation. The experience of 45 cases has shown that 50% of acid and 70% of lye burns will benefit from corticolherapy. If prescribed, it must be given from the third day onwards; earlier administration will impair the proliferation of fibroblasts necessary for repair; afterwards it will be too late to forestall their transformation into fibrocytes responsible for the future and already unpreventable stenosis.

 

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