Age-Associated T-Lymphocyte Activation through Mitogens in Patients with Multiple Sclerosis and Blood Donors
作者:
G. Trenn,
E. Kreuzfelder,
E. Hierholzer,
N. Scheiermann,
H.J. Bauer,
W. Bushart,
期刊:
European Neurology
(Karger Available online 1988)
卷期:
Volume 28,
issue 1
页码: 47-50
ISSN:0014-3022
年代: 1988
DOI:10.1159/000116228
出版商: S. Karger AG
关键词: Age;Healthy persons;Mitogens;Multiple sclerosis;Lymphocyte activation
数据来源: Karger
摘要:
In 128 patients with multiple sclerosis (MS) and 204 blood donors (control persons) the in vitro activation of ‘Ficoll-purified’ peripheral blood T lymphocytes was measured using the 3H-thymidine incorporation rate without (spontaneous proliferation) and with mitogen addition (concanavalin A, phytohemagglutinin). Mitogen responsiveness in control persons and MS patients decreased with age, reflecting a T-lymphocyte inherent mechanism for the diminution of responsiveness. The MS patients, ranging in age between 20 and 30 years, showed decreased mitogen responsiveness and a tendency to increased spontaneous proliferation compared to the control persons. These results could be an expression of a viral infect
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