This article is an overview of adjunct medicines that pain practitioners most commonly use, with a general explanation of how they work. It is intended for the use of all medical personnel in the treatment of neuropathic nociceptive and mixed pain states. It discusses antidepressants, anticonvulsants, local anesthetics, antiarrhythmics, steroids, N-methyl-d-aspartate (NMDA) blockers, topical agents, and muscle relaxants, with emphasis on special drug-drug interactions of which all practitioners should be aware.