Synthesis of14c‐labeled 2,2‐dichloropropionic acid
作者:
F. S. Tanaka,
R. G. Wien,
期刊:
Journal of Labelled Compounds and Radiopharmaceuticals
(WILEY Available online 1976)
卷期:
Volume 12,
issue 1
页码: 41-51
ISSN:0362-4803
年代: 1976
DOI:10.1002/jlcr.2580120107
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractA widely used herbicide, 2,2‐dichloropropionic acid (dalapon), was synthesized with14C‐labeling in the C‐1 or C‐2 positions. The carboxyl labeled material was prepared in 55% yield by carbonation of 1,1‐dichloro‐ethyllithium at approximately −104°. Starting with trichloroacetic acid, the C‐2 labeled product was prepared in an overall yield of 39% by means of a 4‐step reaction sequence which involved the removal of a chlorine atom and the addition
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