Degenerative Changes in Maculas of Rhesus Monkeys
作者:
Harry M. Engel,
William W. Dawson,
Robert J. Ulshafer,
Michael W. Hines,
Matthew J. Kessler,
期刊:
Ophthalmologica
(Karger Available online 1988)
卷期:
Volume 196,
issue 3
页码: 143-150
ISSN:0030-3755
年代: 1988
DOI:10.1159/000309891
出版商: S. Karger AG
关键词: Drusen;Macular Degeneration;Macaca mulatta;Aging macula;Acuity;Primate;Retina;Rhesus monkey;Tuning
数据来源: Karger
摘要:
In the hope of identifying an animal model for age-related macular degeneration (AMD) we undertook a pilot investigation of aged rhesus monkeys. Twenty-nine monkeys from a seminatural colony were examined at the Caribbean Primate Research Center. Macular drusen were found in 74% of the monkey eyes. Alterations of the retinal pigment epithelium within the macula were noted in 45% of the eyes. Fluorescein angiography in selected animals revealed window defects consistent with drusen. None of this sample showed the exudative form of AMD or disciform scarring. One typical monkey underwent special studies including measurement of visual resolution by electrophysiological study of the retinal and visual cortex. Application of human criteria to this animal supported the diagnosis of early AMD. Histopathologic study of one eye by transmission electron microscopy confirmed the presence of drusen with nearly identical ultrastructural features to those found in the human pigment epithelium in AMD.
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