Growth of skeletal muscle from patients with amyotrophic lateral sclerosis transplanted into nude mice
作者:
Adarsh K. Gulati,
Michael H. Rivner,
Morteza Shamsnia,
Thomas R. Swift,
Gurkirpal S. Sohal,
期刊:
Muscle&Nerve
(WILEY Available online 1988)
卷期:
Volume 11,
issue 1
页码: 33-38
ISSN:0148-639X
年代: 1988
DOI:10.1002/mus.880110107
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractWe studied the fate of skeletal muscle obtained from patients with amyotrophic lateral sclerosis (ALS) after transplantation into immunodeficient nude mice. The transplanted muscle consistently survived in the nude mice without immunological rejection. The myofibers in these muscles underwent degeneration, followed by regeneration, maturation, and eventual functional innervation by the mouse motor neurons. The ability to grow diseased human muscle successfully over a prolonged period in nude mice offers an in vivo model to study the etiology of ALS and possibly of other neuromuscular disorders.
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