Changes in Plasma Levels of Prekallikrein, Kallikrein, High Molecular Weight Kininogen and Kallikrein Inhibitors during Lethal Endotoxin Shock in Dogs
作者:
Michael J. Gallimore,
Ansgar O. Aasen,
Egil Amundsen,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1978)
卷期:
Volume 7,
issue 2-3
页码: 79-84
ISSN:1424-8832
年代: 1978
DOI:10.1159/000214239
出版商: S. Karger AG
关键词: Endotoxin;Plasma prekallikrein;Kallikrein;High molecular weight kininogen;α2-Macroglobulin;α1Antitrypsin;Chromogenic peptide substrate
数据来源: Karger
摘要:
Plasma levels of prekallikrein, kallikrein, high molecular weight kininogen and kallikrein inhibitors were measured in samples from dogs infused with E. coli endotoxin. Markedly reduced levels of prekallikrein and high molecular weight kininogen were seen at circulatory collapse and free kallikrein was detected. Both ‘fast-reacting’ and ‘time-dependent’ inhibitors of plasma kallikrein were significantly reduced. Fractionation of pre-infusion and collapse samples by gel filtration together with immunological procedures indicated that both α2-macroglobulin and α1-antitrypsin were the major kallikrein inhibitors in dog plasma, and that they were significantly reduced in the collaps
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