Assessment of Multimeric Structure and Ristocetin‐Induced Binding to Platelets of Von Willebrand Factor Present in Cryoprecipitate and Different Factor VIII Concentrates
作者:
M.F. López‐Fernández,
C. López‐Berges,
M. Corral,
J.R. García‐Talavera,
A. López Borrasca,
J. Batlle,
期刊:
Vox Sanguinis
(WILEY Available online 1987)
卷期:
Volume 52,
issue 1‐2
页码: 15-19
ISSN:0042-9007
年代: 1987
DOI:10.1111/j.1423-0410.1987.tb02981.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Abstract.The multimeric structure of von Willebrand factor (vWF) and its ristocetin‐induced binding to platelets, using a simple and very sensitive radiomonoclonal antibody‐labeled vWF method, was compared in normal plasma, single‐donor cryoprecipitate (CP) and five different antihemophilic factor (AHF) concentrates. All the AHF showed a lack of larger vWF multimers, an abnormal ‘triplet’ pattern, and much lower vWF binding to platelets than that of plasma or CP, vWF being the lowest for those with a lesser proportion of larger vWF multimers. These results suggest that the combination of vWF multimeric analysis and the radiomonoclonal‐labeled vWF method may be very useful in the assessment of AHF p
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