In this work we describe a case of papillophlebitis type II according to Hayreh in a young woman affected by psoriatic arthritis. On the basis of an analysis of the patient’s HLA system – B7, DR7 (characteristics of psoriatic arthritis) and B51 (present in 81% of patients affected by Behçet’s syndrome) – we hypothesize that this may be a case of an ‘Overlap syndrome’. In rheumatology, this term usually refers to the presence in a single patient of characteristic features of two or more diseases. In fact, papillophlebitis is a complication which has never been described in psoriatic arthritis, while, in Behçet’s syndrome, retinal vasculitis is well known.