Structural and Functional Aspects of the Interaction of Inflammatory Cells with the Blood‐Brain Barrier in Experimental Brain Inflammation
作者:
Henryk M. Wisniewski,
Albert S. Lossinsky,
期刊:
Brain Pathology
(WILEY Available online 1991)
卷期:
Volume 1,
issue 2
页码: 89-96
ISSN:1015-6305
年代: 1991
DOI:10.1111/j.1750-3639.1991.tb00645.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Interaction between various subclasses of inflammatory cells (ICs) and endothelial cells (ECs) lining selective blood vessels of the mammalian blood‐brain barrier (BBB) is an initial, important event during inflammatory conditions of the central nervous system (CNS). In this review, we will present a brief ultracytochemical and immunocytochemical assessment of our perspective on this intimate cellular interaction which has been described recently in conditions that involve immunological alterations of the BBB. We will discuss some morphological aspects of what is currently known about acute and chronic inflammatory BBB disorders that are involved in inflammatory processes. We will focus, in particular, on experimental allergic encephalomyelitis (EAE), an animal model for human multiple sclerosis (MS). Many of the past and more recent concepts found in the literature concerning IC attachment and diapedesis, as well as our own experimental efforts over more than two decades will be presente
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