Treatment of Advanced Primary Lung Cancer Associated with Malignant Pleural Effusion by the Combination of Immunotherapy and Chemotherapy
作者:
Hiromi Miyao,
Takaaki Chou,
Kazuhiko Ito,
Hiroyuki Moriyama,
Satoshi Mitsuma,
Masaya Wakabayashi,
Hirohisa Yoshizawa,
Masaaki Arakawa,
期刊:
Oncology
(Karger Available online 1994)
卷期:
Volume 51,
issue 1
页码: 87-94
ISSN:0030-2414
年代: 1994
DOI:10.1159/000227317
出版商: S. Karger AG
关键词: Advanced primary lung cancer;Malignant pleural effusion;Recombinant interleukin-2;In vitro sensitized cells;Anti-CD3-monoclonal-antibody-activated T cells
数据来源: Karger
摘要:
Twelve patients with advanced primary lung cancers associated with malignant pleural effusion were treated with intrathoracic instillation of recombinant interleukin-2 with or without in-vitro-sensitized cells. Two cases achieved complete response, and 7 partial response. The adverse effects seen in the protocol were marginal, and the protocol was well-tolerated and feasible. Furthermore, 4 cases were treated with the combination of systemic chemotherapy and adoptive immunotherapy. Of these, 3 cases responded well to the therapy and have shown a complete response for more than 20 months, indicating that adoptive immunotherapy together with chemotherapy might be a beneficial treatment for advanced lung cancer patients.
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