Different Effects of ACTH Fragments on Hippocampal EEG and Behavior
作者:
Giuliano Fontani,
Fulvio Grazzi,
Maria Aloisi,
期刊:
Neuropsychobiology
(Karger Available online 1987)
卷期:
Volume 17,
issue 3
页码: 169-172
ISSN:0302-282X
年代: 1987
DOI:10.1159/000118357
出版商: S. Karger AG
关键词: ACTH;Hippocampus;Rhythmic slow activity;Behavior;Rabbits
数据来源: Karger
摘要:
The hippocampal electrical activity and behavior of rabbits have been studied in the presence of novel and emotional stimuli. The effects of these stimuli have been recorded in controls and in groups of animals treated with ACTH (4–10) (10 µg/100 g, i.m.) and ACTH (1–24) (10 µg/100 g, i.m.). Recordings were made immediately and 30 min after injection. ACTH (4–10) injection failed to evoke any significant behavioral or electrical response. Rabbits recorded 30 min after ACTH (1–24) injection showed a reduction of hippocampal RSA (rhythmic slow activity) frequency and behavioral activity. In particular, reduction of exploration, self-grooming, motor activity and approaches to the new object have been observed. Since ACTH is characterized by a corticotropic action these results can be due to corticosteroid st
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