AbstractThis paper presents a comparative analysis of the effects of acculturation and acculturative stress on the self‐esteem of Hispanic/Latino adolescents. The study is comparative in that it focuses on variations among both immigrant and native‐born Hispanics. The data were derived from a longitudinal study of adolescents (n= 6,760) being conducted in Miami, Florida. The sample for this paper (n= 4,296) consisted of all the adolescents of Hispanic heritage. A complex patterning of acculturative strains was found for US.‐and foreign‐born adolescents. Acculturation strains and family pride have more powerful effects on self‐esteem as acculturation increases among the foreign born, but the opposite is true for the U.S. born. The proportion of variance explained by the acculturation strains and family pride is greater for the U.S.‐born adolescents (range = 21% to 29%) than for those who are foreign born (range = 15% to 19%). The findings indicate that much of the research on this subject has failed to reflect the differential processes of psychosocial adjustment faced by immigrant and nonimmigrant adolescents. There are differences in the types of strains reported, as well as in the effects of the strains on self‐esteem. Low acculturation adolescents who are U.S. born have an especially problematic profile of strain, whereas bicultural adolescents born in the United States appear to have the best profile. The results suggest a need to advance from simple linear explanations to multifactorial stress models that will increase our understanding of the accultu