The Effects of Cholecystectomy on the Bile Salt Pool of the Syrian Hamster
作者:
W.T. Beher,
G.J. Lin,
S. Stradnieks,
W.N. Konde,
K.S. Rajan,
期刊:
Digestion
(Karger Available online 1977)
卷期:
Volume 15,
issue 4
页码: 338-347
ISSN:0012-2823
年代: 1977
DOI:10.1159/000198020
出版商: S. Karger AG
关键词: Bile acids and salts;Cholecystectomy;Cholic acid;Deoxycholic acid;Glycocholic acid;Hamster;Taurocholic acid
数据来源: Karger
摘要:
The half-life, distribution, size and composition of the bile salt pool were determined in intact and cholecystectomized Syrian hamsters. Cholecystectomy had no effect on the half-life of either the cholate or chenodeoxycholate pool. Fasting in intact hamsters resulted, as expected, in a shift of bile salts from the small intestine, cecum and liver to the gallbladder. In cholecystectomized hamsters there was a moderate shift of salts from the liver and small intestine to the cecum. Cholecystectomy had no significant effect on the size of the total bile salt pool. The total bile salt pool size of fed and fasted intact hamsters was the same; fasting in cholecystectomized hamsters resulted in a large decrease in the pool. There was no significant difference in the bile salt pool composition of intact and cholecystectomized hamsters, and hamsters were shown to efficiently convert deoxycholate to cholate.
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