Carbon Tetrachloride-Induced Experimental Cirrhosis in the Rat: A Reappraisal of the Model
作者:
F. Ariosto,
O. Riggio,
A. Cantafora,
S. Colucci,
E. Gaudio,
C. Mechelli,
M. Merli,
S. Seri,
L. Capocaccia,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 5
页码: 280-286
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129038
出版商: S. Karger AG
关键词: Carbon tetrachloride;Experimental cirrhosis;Zinc;Amino acids
数据来源: Karger
摘要:
The goal of this study was to evaluate the presence of extrahepatic damage and the uniformity and reversibility of the histological findings in CCl4.induced liver cirrhosis in the rat. To verify these findings rats were sacrificed 2 and 10 weeks after a treatment consisting of ten intragastric doses of CCl4, administered weekly. All treated rats developed an irreversible micronodular cirrhosis with no damage to the brain, kidney and pancreas. Moreover, rats sacrificed 2 weeks after the last CCl4 dose showed a number of functional alterations usually observed in man. In particular, low branched chain/aromatic amino acids (BCAA/AAA) plasma ratio, high ammonia, low zinc and high insulin with normal blood glucose were obtained.
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