Intravenous chlorpromazine was found to cause rapid increases in plasma concentrations of glucose and long chain fatty acids in adult sheep of both sexes. α‐adrenergic blockade with phentolamine suppressed the increase in glucose concentration but not the increase in concentration of long chain fatty acids caused by chlorpromazine. β‐adrenergic blockade with propranolol suppressed the increase in concentration of long chain fatty acids but not the increase in glucose concentration caused by chlorpromazine. These results were consistent with the hypothesis that chlorpromazine caused a systemic release of epinep