Potentiation and Its Mechanism of Cochlear Damage Resulting from Furosemide and Aminoglycoside Antibiotics
作者:
J. Ohtani,
K. Ohtsuki,
T. Omata,
J. Ouchi,
T. Saito,
期刊:
ORL
(Karger Available online 1978)
卷期:
Volume 40,
issue 1
页码: 53-63
ISSN:0301-1569
年代: 1978
DOI:10.1159/000275386
出版商: S. Karger AG
关键词: Ototoxic interaction;Furosemide and aminoglycoside antibiotics
数据来源: Karger
摘要:
The severe ototoxic interaction of the combined administration of furosemide and aminoglycoside antibiotics (kanamycin, streptomycin and gentamicin) was studied in rabbits, and its mechanism clarified. Severe damage occurred not only in the inner ear but also in the kidney when both furosemide and aminoglycoside antibiotics were administered to rabbits. Kanamycin concentration after a single injection of kanamycin with furosemide was much higher not only in the perilymph but also in the cerebrospinal fluid and serum than that after a single injection of kanamycin alone. The ototoxic interaction following the combined use of furosemide and aminoglycoside antibiotics seems to be caused mainly by the inhibitory effect of furosemide on the excretion of aminoglycoside antibiotics from the kidneys.
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