Low Doses of Endotoxin Potentiate Venous Thrombosis in the Rabbit
作者:
A. Bernat,
M. Sainte-Marie,
C. Roque,
V. Ingelaere,
J.P. Maffrand,
J.M. Herbert,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1994)
卷期:
Volume 24,
issue 4
页码: 209-218
ISSN:1424-8832
年代: 1994
DOI:10.1159/000217104
出版商: S. Karger AG
关键词: Endotoxin;Venous thrombosis;Procoagulant
数据来源: Karger
摘要:
Procoagulant activity of the endothelium and of monocytes was induced by an intravenous administration of a low dose of endotoxin in the rabbit. Venous thrombosis induced by a 45-min stasis of the jugular vein was dramatically increased after the administration of endotoxin. Endotoxin enhanced venous thrombosis in a dose-dependent manner which was the highest after the administration of 1 µg/kg. This effect increased with time but was optimal when endotoxin was injected 4 h before stasis induction. Leukocytes appear to play a key role in this process since mechlorethamine-induced leukopenia totally inhibited thrombus formation. Hirudin and heparin, administered intravenously 5 min before stasis, were both potent inhibitors of endotoxin-induced venous thrombosis exhibiting ED50 values of 3.8 ± 1.0 and 2.3 ± 1.1 µg/kg, respectiv
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