Quantitative EEG and Neuropsychological Effects of Piracetam and of the Association Piracetam-Lecithin in Healthy Volunteers
作者:
Walter G. Sannita,
Vincenzo Balestra,
Guido Rosadini,
Maurice Salama,
Claudio Timitilli,
期刊:
Neuropsychobiology
(Karger Available online 1985)
卷期:
Volume 14,
issue 4
页码: 203-209
ISSN:0302-282X
年代: 1985
DOI:10.1159/000118228
出版商: S. Karger AG
关键词: Piracetam;Lecithin;Quantitative EEG;Neuropsychological status;Drug plasma concentration
数据来源: Karger
摘要:
The electroencephalographic (EEG) and neuropsychological effects of single, oral doses or piracetam (800–6,400 mg) and of its association with lecithin (4,800 mg and 25 g, respectively) were investigated in two groups of healthy volunteers in placebo-controlled studies. The EEG was quantified by power spectral analysis; both parametric and nonparametric procedures were applied to process the EEG and neuropsychological data statistically. The drug plasma concentration was assessed (gas chromatography) in concomitance with the EEG and neuropsychological measurements. Piracetam was found to elicit systematic EEG effects, namely a decrease in the low-frequency components and an increase in the power of the 8.5- to 12.0-Hz and of the fast-frequency components. The EEG modifications were restricted to the anterior scalp areas; its detection by means of parametric statistics was conditioned by the relevant individual variability and was inferred resting upon a number of criteria (indication at nonparametric tests, topography, consistency across subjects, replicability, etc.). The correlation between EEG changes and drug plasma concentration was ambiguous, and the compound was not found to be effective on any of the neuropsychological variables considered. The study exemplifies some of the methodological problems in quantitative pharmaco-EEG and emphasizes the relevance of topography and replicatio
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