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Tissue Deposition of Bisantrene in B16Melanoma Tumor-Bearing Mice

 

作者: NicolauGabriela,   HuiWen,   McWilliamsWilliam,   CitarellaRonald V.,   DurrFrederick E.,  

 

期刊: Cancer Investigation  （Taylor Available online 1986）
卷期: Volume 4, issue 1  

页码: 25-28

 

ISSN:0735-7907

 

年代: 1986

 

DOI:10.3109/07357908609039824

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractSingle doses of14C-labeled bisantrene, a new antitumor agent, were administered intravenously at 10 and 100 mg/kg to mice bearing intraperitoneally implanted B16melanoma. At 24 hr after dosing, the tumors contained relatively high drug concentrations as compared to most of the other tissues. The concentrations averaged 2.4 and 28.3µg/g tumor and the tumor/blood concentration ratios were 40/1 and 29/1 for the low and high doses, respectively.

 

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