Immunogenicity study of low‐dose administration of hepatitis B virus vaccine in newborn infants: A cost reduction trial
作者:
WHAN KOOK CHUNG,
KYU YONG CHOI,
CHANG LEE,
JIN WU CHUNG,
HEE SIK SUN,
KYU WON CHUNG,
BOO SUNG KIM,
CHUNG SIK CHUN,
KYOO HONG CHO,
SEUNG JO KIM,
期刊:
Journal of Gastroenterology and Hepatology
(WILEY Available online 1987)
卷期:
Volume 2,
issue 1
页码: 13-17
ISSN:0815-9319
年代: 1987
DOI:10.1111/j.1440-1746.1987.tb00144.x
出版商: Blackwell Publishing Ltd
关键词: hepatitis B virus vaccine;immunization;intradermal vaccination;low‐dose vaccine;PreS antibody.
数据来源: WILEY
摘要:
Different doses of hepatitis B virus vaccine—prepared by Korea Green Cross Corporation, were given to healthy infants born to HBsAg‐negative mothers at birth, 1 and 6 months of age. A dose of 2 μg was administered intradermally in Group A and, in the three other groups, the vaccine was given intramuscularly (i.m.). An adequate follow‐up observation was possible for 9 months after birth in 22, 25, 23 and 21 infants in Groups A, B, C and D, respecvely.Group C (5 μg, i.m.) produced seroconversion most rapidly, showing the highest rate (96%) at 9 months of age. The lowest seroconversion rate (5%) was found at the age of 1 month in Group A subjects, but the rate increased to 91% after a booster dose was given at 6 months of age.While it can be concluded that a 5 μg i.m. dose of vaccine at 0, 1 and 6 months of age is optimum for the immunization of infants in efficacy and economy, a 2 μg intradermal dose can also be considered as an immunogenic and economical regimen, though the immune response is slower and a special technique is required for imm
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