A survey of viruses associated with feline respiratory disease was conducted by culturing from 100 swabs collected from cats with respiratory disease and 50 swabs collected from a group of apparently healthy cats. In the first group, 27 herpesviruses and 24 caliciviruses were isolated from 50 cats, whereas 1 herpesvirus and 2caliciviruses were isolated from the second group. Caliciviruses were more commonly isolated from animals under 1 year old and appeared to be more closely associated than herpesviruses with buccal ulceration.