Cross‐reactive and type‐specific complement‐fixing structures of oriboca virions
作者:
Nick Karabatsos,
Robert E. Shope,
期刊:
Journal of Medical Virology
(WILEY Available online 1979)
卷期:
Volume 3,
issue 3
页码: 167-176
ISSN:0146-6615
年代: 1979
DOI:10.1002/jmv.1890030302
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Oriboca virus;complement‐fixing antigens;type‐specific;cross‐reactive;serogroup C;bunyaviruses
数据来源: WILEY
摘要:
AbstractCharacteristics of two components of Oriboca virus were studied after they were separated and semipurified by velocity centrifugation. A component of low infectivity and broad cross‐reactivity in the complement‐fixation (CF) test had a sedimentation coefficient of 6–7S. Infectious Oriboca virions with hemagglutinating (HA) activity had a sedimentation coefficient of 457S. These virions cross‐reacted broadly with Murutucu viral antibody. The crossreactive, virion‐associated component and a type‐specific CF fragment were released from virions by disruption with Nonidet P‐40. These CF fragments separated by sucrose gradient equilibrium centrifugation had densities of 1.245 gm/ml and 1.181 gm/ml, respectively, and were both interpreted to be envelope structures. The type‐specific CF antigen appeared to be related to the viral hemagglutinin in that it blocked hemagglutination‐in‐hibiting (HI) antibody, whereas the cross‐reactiv
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