Changes in Serum Bile Acid Composition in Relation to Histological Findings after Liver Transplantation in Piglets
作者:
T. Okanoue,
M. Kimoto,
A. Maki,
Y. Usui,
N. Nishimura,
N. Kobayashi,
Y. Kamiyama,
K. Ozawa,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 3-4
页码: 145-155
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129017
出版商: S. Karger AG
关键词: Bile acids;Bile acid composition;Liver transplantation;Rejection
数据来源: Karger
摘要:
Changes in the composition of serum bile acids were investigated after orthotopic liver transplantation in piglets. Serum levels of all bile acid components rapidly increased during the anhepatic phase and then quickly decreased, returning to the preoperative state within 6 h of revascularization of the allograft. In the animals in which extrahepatic biliary stenosis was a complication, serum total bile acids (TBA) increased remarkably. A marked increase of hyocholic acid and marked decrease of hyodeoxycholic acid were noted; as percentages of TBA, the average levels per day were 91.3 ± 1.3 and 5.0 ± 1.3%, respectively. No change in chenodeoxycholic acid (CDCA) was observed. In the animals suffering acute rejection without extrahepatic biliary stenosis, serum TBA increased slightly and the percentage of CDCA rose, the average level being 29.6 ± 1.5%. These results suggest that the measurement of the composition of serum bile acids may serve as a useful means of assessing allograft function after liver transplantati
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