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Bactericidal Synergistic Effect due to Chloramphenicol-induced Inhibition of Staphyloccal Penicillinase

 

作者: J. Michel,   J. Jacobs,   T. Sacks,  

 

期刊: Chemotherapy  （Karger Available online 1977）
卷期: Volume 23, issue 1  

页码: 32-36

 

ISSN:0009-3157

 

年代: 1977

 

DOI:10.1159/000221968

 

出版商: S. Karger AG

 

关键词: Synergism;Chloramphenicol;Penicillin-G;Staphylococci;Penicillinase

 

数据来源: Karger

 

摘要:

A synergistic bactericidal effect of chloramphenicol and penicillin-G was observed with 17 out of 20 β-lactamase producing strains of Staphilococcus aureus. The synergism was due to chloramphenicol-induced inhibition of β-lactamase production. With seven of the strains the synergistic effect was operative only with subinhibitory concentrations of chloramphenicol, while higher concentrations produced antagonis

 

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