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Increased in vitro Sensitivity ofCandida albicansto Fluconazole

 

作者: N. Simonetti,   F.D. D’Auria,   V. Strippoli,  

 

期刊: Chemotherapy  （Karger Available online 1991）
卷期: Volume 37, issue 1  

页码: 32-37

 

ISSN:0009-3157

 

年代: 1991

 

DOI:10.1159/000238829

 

出版商: S. Karger AG

 

关键词: Fluconazole;Increased activity in vitro;Sodium dioctyl sulfosuccinate;Surfactant;Minimum inhibitory concentration

 

数据来源: Karger

 

摘要:

Sodium dioctyl sulfosuccinate (SDSS), an anionic surfactant used at a non-antimicrobial concentration, increased the sensitivity of Candida albicans to fluconazole in complex media (such as Sabouraud). The conditions were assessed to determine the in vitro sensitivity to fluconazole. In this connection, the use of a liquid medium at a non-alkaline pH is important. The presence of SDSS in complex media does not seem to affect the neutralization of a particular substances but favours the activity of fluconazole.

 

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