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Susceptibility to Fosfomycin of Hospital Strains Isolated in Nantes (France). Frequency of Mutation to Resistance

 

作者: A.L. Courtieu,   H. Drugeon,   Sylviane Billaudel,  

 

期刊: Chemotherapy  （Karger Available online 1977）
卷期: Volume 23, issue 1  

页码: 25-36

 

ISSN:0009-3157

 

年代: 1977

 

DOI:10.1159/000222023

 

出版商: S. Karger AG

 

关键词: Antibiotic activity;Minimal inhibitory concentrations (MIC);Bacteria;Mutations;Fosfomycin

 

数据来源: Karger

 

摘要:

Susceptibility of 760 bacterial isolates to fosfomycin has been determined by the agar dilution method. The MICs of 364 strains have been determined by comparison of agar alone and agar plus glucose-6-phosphate. This later enhances the activity of fosfomycin. Lastly, we studied frequency of mutation toward resistance for 109 susceptible strains. We obtained 88 stable mutants.

 

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