Combined Action of Fosfomycin withβ-Lactam and Aminoglycoside Antibiotics
作者:
J. Borowski,
H. Linda,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 1
页码: 82-85
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222030
出版商: S. Karger AG
关键词: Synergistic action;Fosfomycin;Penicillin G;Streptomycin;Ampicillin;S. aureus;E. coli;Antibiotic combinations
数据来源: Karger
摘要:
The combined action of fosfomycin with penicillin G, ampicillin and streptomycin was investigated. A total of 11 S. aureus and 10 E. coli were included in these studies. It has been shown that a combination of fosfomycin with penicillin G and streptomycin resulted in a synergistic effect. When S. aureus strains were tested, the combination of fosfomycin with penicillin G was more frequently effective than the combination of fosfomycin with streptomycin. The combination of fosfomycin with ampicillin and streptomycin showed a similar synergistic effect on 7 of 10 E. coli strains. The antagonistic effect never resulted when the above-mentioned combination of antibiotics were used. The authors postulate that a combination of fosfomycin with β-lactam or aminoglycoside antibiotics may be used in clinical practice and such a procedure should prevent an emergence of fosfomycin-resistant strains
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