Effects of Partial Deprivation of Portal Blood on Arterial Blood Ketone Body Ratio in Rabbits
作者:
S. Yamamoto,
N. Nitta,
Y. Kamiyama,
Y. Yamaoka,
K. Ozawa,
期刊:
European Surgical Research
(Karger Available online 1989)
卷期:
Volume 21,
issue 2
页码: 98-104
ISSN:0014-312X
年代: 1989
DOI:10.1159/000129009
出版商: S. Karger AG
关键词: Portal blood deprivation;Arterial blood ketone body ratio;Free NAD+/NADH ratio;Liver mitochondria
数据来源: Karger
摘要:
To examine the effects of portal blood deprivation on energy metabolism of the liver, we studied: (1) the ketone body ratio (acetoacetate/β-hydroxybutyrate) in liver tissue, which is in equilibrium with the free NAD+/NADH ratio in liver mitochondria, in the ligated lobe (LL) and nonligated lobe (NLL), (2) the hepatic energy charge [EC = (ATP + ½ADP)/(ATP + ADP + AMP)] in both LL and NLL, and (3) the arterial blood ketone body ratio (BKBR) after left portal vein branch ligation (PBL) in rabbits. As found in LL after PBL, portal blood deprivation decreased the tissue ketone body ratio. The EC in LL significantly decreased after PBL, but recovered 7 days after PBL since the LL became atrophic. The BKBR remained within the normal range, even when 60% of the total liver was deprived of portal bloo
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