The Use of Oral Methadone to Control Moderate and Severe Pain in Children and Young Adults with Malignancy
作者:
Angela,
Miser James,
期刊:
The Clinical Journal of Pain
(OVID Available online 1985)
卷期:
Volume 1,
issue 4
页码: 243-248
ISSN:0749-8047
年代: 1985
出版商: OVID
关键词: Methadone;Pain;Children;Malignancy
数据来源: OVID
摘要:
Twenty-two courses of oral methadone were given to control moderate or severe pain in 19 children with cancer. Of these, 21 courses gave adequate pain control for periods of 5 to 267 days (median 24 days). In 16 courses, methadone was continued until death or until the pain resolved; in five remaining courses, a change to parenteral narcotics was ultimately required. Toxicity was minimal. A safe starting dose of methadone appears to be 0.1 mg/kg given every 4 hours, or the equivalent total daily dose given less frequently, with escalation as required to achieve and maintain adequate pain control.
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