Over the past few years, increasing emphasis has been placed on the use of antimicrobial agents to prevent opportunistic infections in patients (HIV). This article reviews acute and prophylactic agents, including their side effects, as well as the immunization of AIDS patients. Medications discussed include all classes that are used including antiretroviral therapy. The article includes an easy to use chart of all approved AIDS medication as prepared by the Pharmaceutical Manufacturers Association, including drug name, manufacturer, indications and approval status of the product.