Decreased Levels of Amniotic Fluid Oxytocinase Activity in Preeclampsia
作者:
A.C. Roy,
O.A.C Viegas,
D.K. Sen,
S.S. Ratnam,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1993)
卷期:
Volume 35,
issue 3
页码: 166-168
ISSN:0378-7346
年代: 1993
DOI:10.1159/000292691
出版商: S. Karger AG
关键词: Oxytocin;Prostaglandins;Hypertension;pregnancy-induced;Angiotensin II;Vasopressin;Renin-angiotensin-aldosterone system
数据来源: Karger
摘要:
Oxytocinase (EC 3.4.11.3) activity was determined in 80 amniotic fluid samples obtained from 40 normotensive primigravidas (median age 27 years) and 40 primigravidas (median age 29 years) with pregnancies complicated by preeclampsia between 32 and 39 weeks of gestation. The enzyme activity was significantly lower in preeclampsia than in normal pregnancy with matched gestations (p < 0.01). Considering the possible involvement of vasopressin and angiotensin II in preeclampsia, it is suggested that the enzyme which degrades these pressor hormones may play a role in the pathogenesis of hypertensive pregnancy.
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