Toxicity and Tolerance of 9-(2-Hydroxyethoxymethyl)Guanine
作者:
Keith S. Morgan,
Arden H. Wander,
Herbert E. Kaufman,
Emily D. Varnell,
Terri Creagh-Kirk,
期刊:
Chemotherapy
(Karger Available online 1980)
卷期:
Volume 26,
issue 6
页码: 405-408
ISSN:0009-3157
年代: 1980
DOI:10.1159/000237935
出版商: S. Karger AG
关键词: 9-(2-Hydroxyethoxymethyl)guanine;Antivirals;Herpes;Acyclovir;Zovirax®
数据来源: Karger
摘要:
Acyclovir [9-(2-hydroxyethoxymethyl)guanine] is a new antiviral agent which has specific activity in virus-infected cells. The drug has a high therapeutic index in animal and laboratory models but had not been tested for toxicity in human eyes at the time of this study. A randomized double-blind study on patients requiring antiviral therapy for treatment or prophylaxis of herpetic ocular infections revealed minimal irritation associated with topical administration. Further controlled studies will be necessary to evaluate this compound’s clinical efficac
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