Humoral and cellular immunity to papillomavirus in patients with cervical dysplasia
作者:
Heather A. Cubie,
Mary Norval,
期刊:
Journal of Medical Virology
(WILEY Available online 1988)
卷期:
Volume 24,
issue 1
页码: 85-95
ISSN:0146-6615
年代: 1988
DOI:10.1002/jmv.1890240111
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: human papilloma virus;cell mediated immunity;lymphocyte proliferation assay;humoral immunity;ELISA;cervical intraepithelial neoplasia
数据来源: WILEY
摘要:
AbstractThe cell‐mediated and humoral immune responses to human papillomavirus (HPV) were tested in groups of patients with various degrees of cervical intraepithelial neoplasia (CIN) using a lymphocyte proliferation assay (LPA) as a measure of circulating sensitised T‐cells and an enzyme‐linked immunosorbent assay (ELISA) for antibodies.Twenty‐three of 92 patients (25%) gave stimulation indices (S.I.) greater than two to at least one of the several antigen preparations tested in the LPA. Of 282 patients, 144 (50.1%) showed ELISA indices (E.I.) greater than one to HPV‐1 and/or HPV‐2 antigens prepared by disruption of purified virions.No correlation was found between positive responses in either test and the presence in cervical biopsies of koilocytes (considered pathognomonic for HPV infections), or between positive responses and the degree of dysplasia observed. Rather, positive antibody and T‐cell responses corresponded with a history of past or present skin warts. Although antibody was detected in 42/86 (48.8%) women who thought they had never had warts, only 2/24 (8.3%) with no known history gave a positiv
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