Genetic control of eosinophilia in guinea pig strains inbred for high or low bronchial allergic reactivity
作者:
M. P. Winthereik,
L. Lundberg,
J. V. Spärck,
T. Katzenstein,
D. Sompolinsky,
期刊:
Allergy
(WILEY Available online 1992)
卷期:
Volume 47,
issue 2PART1
页码: 103-109
ISSN:0105-4538
年代: 1992
DOI:10.1111/j.1398-9995.1992.tb05096.x
出版商: Blackwell Publishing Ltd
关键词: asthma;blood eosinophilia;eosinophilic granulocyte;(strains of) guinea pigs
数据来源: WILEY
摘要:
Development of eosinophilia was studied in four strains of guinea pigs (gp), selectively bred for either high or low respiratory anaphylactic reactivity. One high‐asthma strain (IMM/S 209) and one low‐asthma strain (IMM/R 203) developed spontaneous high blood eosinophilia. The 2 other gp strains ‐ one high‐asthma strain (IMM/S 740) and one low‐asthma strain (IMM/R 201–16) – maintained normal low levels of eosinophilic granulocytes (eos). The levels of eos in various tissues showed similar differences between the gp strains. Following immunization with ovalbumin/Al(OH)3the levels of blood eos increased significantly only in gp of strain 209. The blood eos levels in gp of all 4 strains decreased significantly following immunization with ovalbumin in Freund's complete a
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