Cell-Mediated Immunity in Chronic Myelocytic Leukemia
作者:
P. Hernández,
C. Cruz,
N.L. Fernández,
M.N. Santos,
J.M. Ballester,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 67,
issue 4
页码: 249-254
ISSN:0001-5792
年代: 1982
DOI:10.1159/000207071
出版商: S. Karger AG
关键词: Cellular immunity;Chronic myelocytic leukemia;E rosette;PHA transformation;Skin tests
数据来源: Karger
摘要:
14 patients with chronic myelocytic leukemia were evaluated immunologically; no difference was found in mean lymphocyte percentage and absolute number between patients and healthy subjects. 4 cases (28.5%) showed decreased percentage of T lymphocytes, while only 2 cases (14.2%) had decreased absolute T lymphocyte values. PHA transformation was decreased in 57% of the patients, Spontaneous transformation in the short-term cultures exceeded the normal range in 65% of the cases. All patients skin tested were found to be reactive. Most of the patients had defective cellular immune response in vitro, probably related with a qualitative defect in T lymphocyte subpopula-tions. It cannot be completely excluded that part of the observed lymphocyte depression was due to the busulfan.
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