Use of serotype‐specific monoclonal antibodies to study the epidemiology of rotavirus infection
作者:
C. J. Birch,
R. L. Heath,
I. D. Gust,
期刊:
Journal of Medical Virology
(WILEY Available online 1988)
卷期:
Volume 24,
issue 1
页码: 45-53
ISSN:0146-6615
年代: 1988
DOI:10.1002/jmv.1890240107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: faecal EIA;epidemiology of rotavirus serotypes
数据来源: WILEY
摘要:
AbstractThe development of an enzyme immunoassay (EIA) capable of serotyping human rotavirus (HRV) in faecal extracts has enabled us to retrospectively study the epidemiology of rotavirus infection in Melbourne. Of 552 stored specimens obtained from individuals with rotavirus‐associated gastroenteritis between 1975 and 1986, the serotype could be determined in 62%. Infection was most prevalent in two groups, neonates and children aged between 12 and 24 months. In these groups infection was due to different serotypes, type 1 in older children and an untypable virus in infants. Serotype 1 strains were detected in greater numbers than the other serotypes and circulated in each year of the study. Serotype 2 rotaviruses were associated with a large epidemic in 1978, but have been detected only rarely sinc
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