Antiviral effect of flavonoids on human viruses
作者:
Tej N. Kaul,
Elliott Middleton,
Pearay L. Ogra,
期刊:
Journal of Medical Virology
(WILEY Available online 1985)
卷期:
Volume 15,
issue 1
页码: 71-79
ISSN:0146-6615
年代: 1985
DOI:10.1002/jmv.1890150110
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: respiratory syncytial virus;poliovirus;parainfluenza virus;herpes virus;flavonoids;quercetin;antiviral agents
数据来源: WILEY
摘要:
AbstractThe effect of several naturally occurring dietary flavonoids including quercetin, naringin, hesperetin, and catechin on the infectivity and replication of herpes simplex virus type 1 (HSV‐I), polio‐virus type 1, parainfluenza virus type 3 (Pf‐3), and respiratory syncytial virus (RSV) was studied in vitro in cell culture monolayers employing the technique of viral plaque reduction. Quercetin caused a concentration‐dependent reduction in the infectivity of each virus. In addition, it reduced intracellular replication of each virus when monolayers were infected and subsequently cultured in medium containing quercetin. Preincubation of tissue culture cell monolayers with quercetin did not affect the ability of the viruses to infect or replicate in the tissue culture monolayers. Hesperetin had no effect on infectivity but it reduced intracellular replication of each of the viruses. Catechin inhibited the infectivity but not the replication of RSV and HSV‐1 and had negligible effects on the other viruses. Naringin had no effect on either the infectivity or the replication of any of the viruses studied. Thus, naturally occurring flavonoids possess a variable spectrum of antiviral activity against certain RNA (RSV, Pf‐3, polio) and DNA (HSV‐1) viruses acting to inhibit infectivity and/o
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